Tissue arrays, or tissue
microarrays (TMAs), are usually produced by a method of re-locating tissue from
conventional histologic paraffin blocks. Through TMAs, researchers get an
example of what a tissue microarray and its construction is, as well as knowing
what are the completed colon cancer array and spots from this array and a
melanoma array.
All of this can be achieved
by a hollow needle, which is used to biopsy a standard histologic sections and
placing the core (which is as small as 0.6 mm in diameter) into an array on a
recipient paraffin block.
As early as 28 years ago,
this technique has been described by two people named Wan, Fortuna, and
Furmanski, who put forward their ideas in Journal of Immunological Methods.
However, the TMAs technique was actually popularized after a publication in
Nature Medicine in 1998, written by Kononen and colleagues in the laboratory of
Ollie Kallioneimi.
Nowadays, Tissuemicroarrays (TMAs) provide research communities a means for rapid,
large-scale analysis of several hundred tissue specimens.
This High-throughput genome
screening technology has also made it possible to survey thousands of genes at
a time from tissues and cells. There was no doubting that the translation of
such information to improve diagnostic, prognostic and therapeutic applications
requires extensive validation.
Creative Bioarray’s tissue
arrays help scientists and researchers efficiently analyze gene and protein
expressions in multiple tissue samples. We can provide you this high-throughput
technique---TMAs, which allows rapid gene expression and copy-number surveys of
large numbers of different tissue specimens.
Moreover, based on the
availability of more than 500,000 human and 30,000 animal samples in our tissue
bank, we have the ability to construct high quality tissue arrays to satisfy your
special requirements.
Besides, we have also
established standard operation procedure in custom array service. Our tissue
microarrays are produced by re-locating tissues from conventional histological
blocks. Typically, 40 to 1,000 cylindrical formalin-fixed and paraffin-embedded
tissue cores can be densely and precisely arrayed into a single paraffin block.
From the block, up to 300 serial 4-8 μm thick sections can
be produced and placed on individual glass microscopic slides.
With our professional support
and technique, you can have all your required Custom Tissue Array provided by us
Creative Bioarray. So, please don't hesitate to call us at 1-631-626-9181 or
email to info@creative-bioarray.com for further
details.
We are very interested in your tissue array services and hope to have a further cooperation.
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